Feeling wired or jittery after drinking coffee is a sign of increased adrenal output, or hyperadrenalism, a need for liver support or insensitivity to coffee. Increased cortisol with a concomitant low DHEA causes symptoms of being wired and jittery. When you add caffeine, an adrenal stimulant into the body, you will get an exacerbation of the hyperadrenal symptoms. Caffeine is a drug that needs to be detoxified by the liver. If a person does not handle caffeine very well, it is a sign of liver support, especially the Phase I detoxification. In the beginning stages of adrenal decompensation the body's response to stress is to increase the cortical output from the adrenal
glands. An insensitivity to coffee and caffeine in general can cause a person to be wired and jittery after coffee.
Reference: Weatherby, D. (2004). Signs and Symptoms Analysis from a Functional Perspective. Jacksonville, OR: Bear Mountain Publishing.